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DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5` UTR or in the 3` coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].


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TRANSCRIPTS LIST

5'/3'UTRs Partially Coding Exons Coding Exons Introns


Promoter 3'UTR

DYRK1A_HF584751

Gene: NM:DYRK1A_HF584751 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 intron 1 intron 2
Promoter 3'UTR

DYRK1A_HF584752

Gene: NM:DYRK1A_HF584752 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 intron 1 intron 2





Updated on June 12, 2013