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DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5` UTR or in the 3` coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].


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TRANSCRIPTS LIST

5'/3'UTRs Partially Coding Exons Coding Exons Introns


Promoter 3'UTR

NM_101395; ENST00000338785.3

Gene: NM:NM_101395; ENST00000338785.3 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 EXON 11 EXON 11 EXON 12 EXON 12 EXON 13 EXON 13 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9 INTRON 10 INTRON 11 INTRON 12
Promoter 3'UTR

ENST00000451934.1

Gene: NM:ENST00000451934.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9
Promoter 3'UTR

NM_130436; ENST00000339659.3

Gene: NM:NM_130436; ENST00000339659.3 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 EXON 11 EXON 11 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9 INTRON 10
Promoter 3'UTR

NM_001396; ENST00000398960.2

Gene: NM:NM_001396; ENST00000398960.2 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 EXON 11 EXON 11 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9 INTRON 10
Promoter 3'UTR

NM_130438; ENST00000398956.2

Gene: NM:NM_130438; ENST00000398956.2 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9
Promoter 3'UTR

ENST00000462274.1

Gene: NM:ENST00000462274.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 INTRON 1 INTRON 2 INTRON 3 INTRON 4
Promoter 3'UTR

ENST00000455097.1

Gene: NM:ENST00000455097.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 INTRON 1 INTRON 2 INTRON 3
Promoter 3'UTR

ENST00000426672.1

Gene: NM:ENST00000426672.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 INTRON 1 INTRON 2 INTRON 3 INTRON 4
Promoter 3'UTR

ENST00000321219.8

Gene: NM:ENST00000321219.8 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 EXON 11 EXON 11 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9 INTRON 10
Promoter 3'UTR

ENST00000498351.1

Gene: NM:ENST00000498351.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 INTRON 1 INTRON 2
Promoter 3'UTR

ENST00000455387.2

Gene: NM:ENST00000455387.2 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6





Updated on June 12, 2013