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DNMT3L

DNA (cytosine-5-)-methyltransferase 3-like

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined. [provided by RefSeq, Jul 2008].


  Gene Expression Pattern     Gene Network    dbSNP    OMIM  


TRANSCRIPTS LIST

5'/3'UTRs Partially Coding Exons Coding Exons Introns


Promoter 3'UTR

NM_013369; ENST00000270172.3

Gene: NM:NM_013369; ENST00000270172.3 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 EXON 11 EXON 11 EXON 12 EXON 12 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9 INTRON 10 INTRON 11
Promoter 3'UTR

NM_175867; ENST00000418993.1

Gene: NM:NM_175867; ENST00000418993.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 EXON 11 EXON 11 EXON 12 EXON 12 EXON 13 EXON 13 EXON 14 EXON 14 EXON 15 EXON 15 EXON 16 EXON 16 EXON 17 EXON 17 EXON 18 EXON 18 EXON 19 EXON 19 EXON 20 EXON 20 EXON 21 EXON 21 EXON 22 EXON 22 EXON 23 EXON 23 EXON 24 EXON 24 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9 INTRON 10 INTRON 11 INTRON 12 INTRON 13 INTRON 14 INTRON 15 INTRON 16 INTRON 17 INTRON 18 INTRON 19 INTRON 20 INTRON 21 INTRON 22 INTRON 23
Promoter 3'UTR

ENST00000436357.1

Gene: NM:ENST00000436357.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 EXON 11 EXON 11 EXON 12 EXON 12 EXON 13 EXON 13 EXON 14 EXON 14 EXON 15 EXON 15 EXON 16 EXON 16 EXON 17 EXON 17 EXON 18 EXON 18 EXON 19 EXON 19 EXON 20 EXON 20 EXON 21 EXON 21 EXON 22 EXON 22 EXON 23 EXON 23 EXON 24 EXON 24 EXON 25 EXON 25 EXON 26 EXON 26 EXON 27 EXON 27 EXON 28 EXON 28 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9 INTRON 10 INTRON 11 INTRON 12 INTRON 13 INTRON 14 INTRON 15 INTRON 16 INTRON 17 INTRON 18 INTRON 19 INTRON 20 INTRON 21 INTRON 22 INTRON 23 INTRON 24 INTRON 25 INTRON 26 INTRON 27
Promoter 3'UTR

ENST00000431166.1

Gene: NM:ENST00000431166.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 EXON 11 EXON 11 EXON 12 EXON 12 EXON 13 EXON 13 EXON 14 EXON 14 EXON 15 EXON 15 EXON 16 EXON 16 EXON 17 EXON 17 EXON 18 EXON 18 EXON 19 EXON 19 EXON 20 EXON 20 EXON 21 EXON 21 EXON 22 EXON 22 EXON 23 EXON 23 EXON 24 EXON 24 EXON 25 EXON 25 EXON 26 EXON 26 EXON 27 EXON 27 EXON 28 EXON 28 EXON 29 EXON 29 EXON 30 EXON 30 EXON 31 EXON 31 EXON 32 EXON 32 EXON 33 EXON 33 EXON 34 EXON 34 EXON 35 EXON 35 EXON 36 EXON 36 EXON 37 EXON 37 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9 INTRON 10 INTRON 11 INTRON 12 INTRON 13 INTRON 14 INTRON 15 INTRON 16 INTRON 17 INTRON 18 INTRON 19 INTRON 20 INTRON 21 INTRON 22 INTRON 23 INTRON 24 INTRON 25 INTRON 26 INTRON 27 INTRON 28 INTRON 29 INTRON 30 INTRON 31 INTRON 32 INTRON 33 INTRON 34 INTRON 35 INTRON 36





Updated on June 12, 2013