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CLDN8

claudin 8

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.


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TRANSCRIPTS LIST

5'/3'UTRs Partially Coding Exons Coding Exons Introns


Promoter 3'UTR

ENST00000399899.1

Gene: NM:ENST00000399899.1 EXON 1 EXON 1
Promoter 3'UTR

ENST00000286809.1

Gene: NM:ENST00000286809.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 INTRON 1 INTRON 2
Promoter 3'UTR

ENST00000536721.1

Gene: NM:ENST00000536721.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 INTRON 1 INTRON 2 INTRON 3 INTRON 4
Promoter 3'UTR

NM_199328

Gene: NM:NM_199328 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5





Updated on June 12, 2013