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BACE2

beta-site APP-cleaving enzyme 2

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer`s disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the `Down critical region` of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].


  Gene Expression Pattern     Gene Network    dbSNP    OMIM  


TRANSCRIPTS LIST

5'/3'UTRs Partially Coding Exons Coding Exons Introns


Promoter 3'UTR

NM_138992; ENST00000328735.6

Gene: NM:NM_138992; ENST00000328735.6 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7
Promoter 3'UTR

NM_138991; ENST00000347667.4

Gene: NM:NM_138991; ENST00000347667.4 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7
Promoter 3'UTR

NM_012105; ENST00000330333.6

Gene: NM:NM_012105; ENST00000330333.6 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8
Promoter 3'UTR

ENST00000544566.1

Gene: NM:ENST00000544566.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 EXON 9 EXON 9 EXON 10 EXON 10 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7 INTRON 8 INTRON 9
Promoter 3'UTR

ENST00000470864.1

Gene: NM:ENST00000470864.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 INTRON 1 INTRON 2 INTRON 3
Promoter 3'UTR

ENST00000487994.1

Gene: NM:ENST00000487994.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7
Promoter 3'UTR

ENST00000491838.1

Gene: NM:ENST00000491838.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 INTRON 1 INTRON 2 INTRON 3 INTRON 4
Promoter 3'UTR

ENST00000466122.1

Gene: NM:ENST00000466122.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 EXON 8 EXON 8 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6 INTRON 7
Promoter 3'UTR

ENST00000465326.1

Gene: NM:ENST00000465326.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 EXON 7 EXON 7 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5 INTRON 6
Promoter 3'UTR

ENST00000463674.1

Gene: NM:ENST00000463674.1 EXON 1 EXON 1 EXON 2 EXON 2 EXON 3 EXON 3 EXON 4 EXON 4 EXON 5 EXON 5 EXON 6 EXON 6 INTRON 1 INTRON 2 INTRON 3 INTRON 4 INTRON 5
Promoter 3'UTR

ENST00000475618.1

Gene: NM:ENST00000475618.1 EXON 1 EXON 1 EXON 2 EXON 2 INTRON 1





Updated on June 12, 2013